Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke


The 'Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke' (TARDIS) trial is a collaborative, international, multicentre, prospective, randomised, blinded endpoint, parallel-group, controlled trial testing the safety and efficacy of one month of intensive antiplatelet therapy (combined aspirin, clopidogrel and dipyridamole) in comparison with guideline antiplatelet therapy (aspirin and dipyridamole) in patients with acute ischaemic stroke or TIA

4,100+ patients with acute ischaemic stroke or high risk TIA are enrolled within 48 hours of onset. The primary outcome is the frequency and severity of recurrent cerebrovascular events determined at 90 days by observers blinded to treatment. The BHF-funded start-up phase tested the safety, feasibility and tolerability of the trial and interventions. The main phase of the trial is funded by the HTA.

If you are interested in having your centre join the trial, please fill in an Expression of Interest form and send/fax to the Coordinating Centre as per details at bottom of form.

Trial synopsis, V1.0 (pdf)

2016, April: TARDIS is now closed to recruitment. Please would Investigators continue to follow-up all patients as per the protocol, and speedily address requests from the Coordinating Centre for data validation and correction. The final results based on cleaned and locked data will be presented and published, hopefully before end of 2016; until then they will be confidential (as with other large trials). Please follow national stroke guidelines for all treatment decisions. Many thanks for taking part in this important study.

TARDIS trial website and database

Enter LIVE TARDIS trial web-site


As of close of recruitment (13th April 2016):

Enrolled patients: 3096 - ischaemic stroke 2148 (69.4%), TIA 948 (30.6%)
Guideline split in stroke: Clopidogrel 58.8%, aspirin/dipyridamole 41.2%
Guideline split in TIA: Clopidogrel 46.8%, aspirin/dipyridamole 53.2%
Centres in the UK: 124
Centres in Europe: 6
Centres in Oceania: 1
Total centres: 131

Tweets by @tardistrial


Forthcoming events

TARDIS will be attending:


TARDIS in the News

TARDIS: Triple Antiplatelet Therapy No Benefit in Stroke, TIA Medscape Neurology, 24 Feb 2017
Safety and efficacy of Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke: the TARDIS randomised controlled trial NIHR Journal Library, 26 Jan 2017
TARDIS trial seeks new dimension in stroke treatment Medical Xpress, 17 Oct 2011
TARDIS trial seeks new dimension in stroke treatment HealthCanal, 17 Oct 2011
TARDIS trial seeks new dimension in stroke treatment University of Nottingham, 17 Oct 2011
Triple cocktail to tackle stroke risk, 17 Sept 2008

The Virtual Medical Centre has produced some videos with Lesley Cala, scan adjudicator on TARDIS, which involve TARDIS:
        'Improving Stroke Outcomes' (link), 10/09/2015
For the following video you will need to sign up here: this is free but only registered health professionals (who input the required registration numbers) will be able to view this video.
        TARDIS, TICH and TICH-2 trials (link), 11/09/2015.


Newsletter 23 - July 2017 (pdf)
Newsletter 22 - May 2017 (pdf)
Newsletter 21 - September 2016 (pdf)
Newsletter 20 - August 2016 (pdf)
Newsletter 19 - May 2016 (pdf)
Newsletter 18 - March 2016 (pdf)
Newsletter 17 - September 2015 (pdf)
Newsletter 16 - May 2015 (pdf)
Newsletter 15 - September 2014 (pdf)
Newsletter 14 - July 2014 (pdf)
Newsletter 13 - January 2014 (pdf)
Newsletter 12 - November 2013 (pdf)
Newsletter 11 - July 2013 (pdf)
Newsletter 10 - March 2013 (pdf)
Newsletter 9 - July 2012 (pdf)
Newsletter 8 - January 2012 (pdf)
Newsletter 7 - October 2011 (pdf)
Newsletter 6 - August 2011 (pdf)
Newsletter 5 - April 2011 (pdf)
Newsletter 4 - December 2010 (pdf)
Newsletter 3 - August 2010 (pdf)
Newsletter 2 - April 2010 (pdf)
Newsletter 1 - December 2009 (pdf)


Demo/practice website and database

Enter DEMO TARDIS demonstration/practice trial web-site

Study personnel

Trial Steering Committee:

Former Members:
Ossie Newell (Patient representative, Nottingham)

International Advisory Committee:
Denmark - Hanne Christensen, Georgia - Maia Beridze, New Zealand - Anna Ranta

Trial Management Committee (Nottingham):
Philip Bath (Chair), Diane Havard (Trial Manager), Margaret Adrian (UK Trial Coordinator), Michael Stringer (UK Trial Coordinator), Jamie Longmate (UK Trial Coordinator), Jason Appleton (Medic), Lisa Woodhouse (Statistician), Mark Sampson (Data and Imaging), Wim Clarke (Financial), Yvonne Smallwood (Secretary)

Former Members:
Sally Utton (Trial Manager), Hayley Foster (Trial Manager), Harriet Howard (UK Trial Coordinator), Tanya Payne (UK Trial Coordinator), Alice Durham (International Trial Coordinator), Joanne Keeling (International Trial Coordinator; Outcome Coordinator), Sharon Ellender (International Trial Coordinator; Outcome Coordinator), Sarah Grant (International Trial Coordinator; Outcome Coordinator), James Kirby (International Trial Coordinator; Outcome Coordinator), Lynsey Cobane (Outcome Coordinator), Jennifer Smithson (Outcome Coordinator), Gemma Walker (Outcome Coordinator), Kailash Krishnan (Medic), Cheryl Hogg (Statistician), Aimee Houlton (Statistician), Katie Flaherty (Statistician), Dawn Hazle (Data and Imaging), Tanya Jones (Data and Imaging), Lauren Dunn (Secretary)

Independent Data Monitoring Committee:
Ian Ford (Glasgow, Chair), Didier Leys (Lille, Belgium), Cathie Sudlow (Edinburgh), Matthew Walters (Glasgow)

Outcome & SAE Adjudicators:
Nikola Sprigg (Nottingham), Marc Randall (Leeds), Kailash Krishnan (Nottingham), Wayne Sunman (Nottingham)

Neuroimaging Adjudicators:
Rob Dineen (Nottingham), Alessandro Adami (Verona, Italy), Lesley Cala (Perth, Australia), Ana Casado (Edinburgh), Rebecca Gallagher (Nottingham), David Sweinton (Nottingham)

Platelet substudy:
Stan Heptinstall, Sue Fox, Jane May (Nottingham)

Other members:
Richard Donnelly (Vascular Medicine, Derby), Alan Montgomery (Statistician, Nottingham)

Programming/database management:
Richard Dooley, Liz Walker (UK)
Formerly: Lee Haywood (UK), Graham Watson (UK)

Contact details

TARDIS Trial Office
Stroke, Division of Clinical Neuroscience
University of Nottingham
Clinical Sciences Building
City Hospital Campus
Hucknall Road
Telephone: +44 115 823 1770
Fax: +44 115 823 1771

Written by Philip Bath, last updated by Mark Sampson 13 September 2017

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